Comment on “Effect of an Endoscopy Screening on Upper Gastrointestinal Cancer Mortality: A Community-Based Multicenter Cluster Randomized Clinical Trial”



We commend Xia et al1 for their ambitious cluster randomized trial evaluating the impact of endoscopic screening on upper gastrointestinal (UGI) cancer mortality. The study provides critical evidence for population-based screening strategies. However, several methodologic and interpretative limitations undermine the validity of the conclusions and warrant urgent clarification.

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