Glutaminase 2-Mediated Yes Associated Protein 1 Glutamylation Facilitates Immune Evasion in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging cancers to treat, primarily due to its immunosuppressive tumor microenvironment and poor response to immune checkpoint inhibitors.1 Yes associated protein 1 (YAP1), a key effector of the Hippo pathway, regulates pivotal processes such as proliferation, survival, and differentiation in PDAC.2,3 Zinc-dependent regulation of zinc finger E-box-binding homeobox 1 (ZEB1), a transcription factor, has been shown to interact with YAP1, promoting epithelial-mesenchymal transition (EMT) plasticity and metastasis in PDAC.
