The Impact of Hepatitis B Surface Antigen Reduction via Small Interfering RNA Treatment on Natural and Vaccine (BRII-179)-Induced Hepatitis B Vaccine-Specific Humoral and Cellular Immune Responses



The immune response in chronic hepatitis B virus patients receiving a combination of the therapeutic vaccine BRII-179 and siRNA elebsiran was characterized, and improved humoral immunity and enhanced Pre-S1/Pre-S2–specific cluster of differentiation 4-positive T-cell responses were detected.

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