The emergence of cancer drug resistance remains one of the most pressing problems in cancer care and there is a critical need to devise approaches to mitigate it. However, the ...
Spatial and Functional Specialization of Gut Enterochromaffin Cells in Sensory Signaling
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Baghdadi MB, Houtekamer RM, Perrin L, et al. Piezo-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance. Science 2024;386(6725):eadj7615.
Researchers at the University of Colorado Anschutz Medical Campus have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing ...
For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level ...
Stem cells sourced from precancerous lesions detail the 20-year evolution of esophageal cancer and support drug discovery for preemptive therapeutics.
Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...
Perforin generated by colonic CD8+ T cells promotes intestinal epithelial cell CXCL9 production, which leads to neuronal endoplasmic reticulum stress in hippocampus and induces depression in ...
We read with great interest the study by Horn et al1 on circulating effector CD4+ T cells as predictors of response to integrin α4β7–blocking therapy in inflammatory bowel disease (IBD). Their ...
